blinky and pinky ! ! ! !
Since Pinky tries approaching the point four squares in front of Pac-Man, it is possible to trick Pinky into turning away. For example, if you just turned an intersection with Pinky hot in pursuit, a quick reversal will distract him into moving in the wrong direction - but this won't always work.
In general, Pac-Man's survival depends on staying farther away from Blinky and Pinky, even if it means getting closer to Inky and Clyde. After you grab a power pellet, and if you have the opportunity, you should eat Blinky and Pinky first to keep them out of play for a longer time.